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DIVERSITY OF GLUTATHIONE S-TRANSFERASE OMEGA 1 (A140D) AND 2 (N142D) GENE POLYMORPHISMS IN WORLDWIDE POPULATIONS

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SUMMARY



Glutathione S-transferase class omega (GSTO) 1 and 2 are members of the glutathione-S-transferase family, which uses glutathione in the process of the biotransformation of drugs, xenobiotics and oxidative stress. Associations with the age-at-onset of Alzheimer's and Parkinson's diseases have been shown in the genetic polymorphism of GSTO1 and GSTO2.



In the present study, the frequencies of GSTO1*A140D and GSTO2*N142D in Ovambos (n = 163), Turks (n = 194), Mongolians (n = 243) and Japanese (n = 102) were investigated and compared with findings from other studies. Detection of these single nucleotide polymorphisms was performed by polymerase chain reaction–restriction fragment length polymorphism analysis.



The allele frequencies of these polymorphisms in Ovambos, Turks, Mongolians and Japanese were 0.040, 0.085, 0.128 and 0.108, respectively, for GSTO1*A140D and 0.583, 0.219, 0.173 and 0.216, respectively, for GSTO2*N142D. Ovambos showed the lowest allele frequency of GSTO1*A140D. Conversely, Africans, including Ovambos, showed higher allele frequencies of GSTO2*N142D than Caucasians and Asians.



The existence of a certain genetic heterogeneity in the worldwide distribution of these two polymorphisms is revealed in the present study.
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Keywords: Japanese; Mongolians; Ovambos; Turks; glutathione S-transferase class omega (GSTO) 1 and 2; polymorphism

Document Type: Research Article

Publication date: March 1, 2009

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