Skip to main content
padlock icon - secure page this page is secure

SIMULTANEOUS MODELLING OF THE MICHAELIS-MENTEN KINETICS OF PARACETAMOL SULPHATION AND GLUCURONIDATION

Buy Article:

$52.00 + tax (Refund Policy)

SUMMARY



The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP).



A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. Plasma samples were collected over 24 h and urine was collected for 8 h after dosing. Twenty patients were enrolled in the study and complete data for plasma and urine were available for both doses for 13 volunteers who were included in the analysis; seven of the volunteers were men, the median age (range) was 22 years (19–31) and the median weight (range) was 68 kg (50–86).



The mean (95% CI) km for APAP glucuronidation was 6.89 mmol/L (3.57–10.22) and the Vmax was 0.97 mmol/h per kg (0.65–1.28). The km for APAP sulphation was 0.097 mmol/L (0.041–0.152) and the Vmax was 0.011 mmol/h per kg (0.009–0.013). For the combined excretion of APAP-cysteine and APAP-mercapturate, the km was 0.303 mmol/L (0.131–0.475) and the Vmax was 0.004 mmol/h per kg (0.002–0.005).



The estimates for in vivo Michaelis-Menten constants for APAP glucuronidation and sulphation were in the order of those reported previously using in vitro methods.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Michaelis-Menten; glucuronidation; metabolism; paracetamol; sulphation

Document Type: Research Article

Publication date: January 1, 2009

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more