Skip to main content
padlock icon - secure page this page is secure

ANGIOTENSIN II-MEDIATED VASODILATION IS REDUCED IN ADULT SPONTANEOUSLY HYPERTENSIVE RATS DESPITE ENHANCED EXPRESSION OF AT2 RECEPTORS

Buy Article:

$52.00 + tax (Refund Policy)

SUMMARY



The vasodilator action of angiotensin (Ang) II has not yet been demonstrated in spontaneously hypertensive rats (SHR), nor have any possible changes in this response during the development of hypertension.



In the present study, the vasodilator effect of AngII was evaluated in the rat isolated, preconstricted mesenteric arterial bed (MAB) from 6- (young) and 24-week-old (adult) SHR and compared with effects on MAB from age-matched normotensive rats (control).



Angiotensin II (10–300 nmol) induced vasodilation in noradrenaline (NA)-preconstricted MAB that was greater in vessels from young compared with adult rats in both the control and SHR groups. Angiotensin II-induced vasodilation was reduced by the angiotensin AT2 receptor antagonist PD 123319 (10 µmol/L), the angiotensin-(1–7) receptor antagonist A779 (1 µmol/L) and the bradykinin B2 receptor antagonist HOE-140 (0.01 µmol/L), but not by the AT1 receptor antagonist losartan (30 µmol/L). Expression of AT2 receptors was weak in vessels from adult control rats compared with that in young control rats, whereas in young SHR AT2 receptor expression was increased compared with that in young control rats. This increased expression of AT2 receptors was maintained in adult SHR and there was no significant difference in AT2 receptor expression between young and old SHR.



The findings of the present suggest that AngII induces an AT2 receptor-mediated vasodilator effect in the MAB via activation of angiotensin-(1–7) and bradykinin receptors, an action that is reduced in adult control rats and adult SHR. In adult control rats, the attenuated response of AngII is probably due to endothelial dysfunction and reduced expression of AT2 receptors, whereas in adult SHR it is associated with endothelial dysfunction alone. Increased expression of AT2 receptors in SHR may represent a counteracting response for modulating blood pressure.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: AT2 receptors; angiotensin 1–7; angiotensin II; bradykinin; hypertension; vasodilation

Document Type: Research Article

Publication date: January 1, 2009

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more