Skip to main content
padlock icon - secure page this page is secure

PROGRESSION OF SEVERE ATHEROSCLEROSIS AND INCREASED ARTERIAL PULSE PRESSURE IN THE NEWLY DEVELOPED HERITABLE MIXED HYPERLIPIDAEMIC RABBITS

Buy Article:

$47.00 + tax (Refund Policy)

SUMMARY



 We have recently segregated a new line of rabbit, named TGH, with severely high levels of plasma triglyceride and cholesterol. The aim of the present study was to investigate the progression of atherosclerosis and haemodynamic parameters in TGH rabbits.



Japanese white (JW) and TGH rabbits (24–27 months old) were anaesthetized with ketamine and xylazine. Plasma concentrations of triglyceride were 63.1  8.0 and 446.0  35.2 mg/dL in JW and TGH rabbits, respectively. Blood pressure was measured by a catheter implanted in the femoral artery. Histological examinations were performed using haematoxylin–eosin and elastica–Masson trichrome staining to detect atherosclerotic lesions.



The JW rabbits had no atherosclerotic lesions. In TGH rabbits, severe atherosclerotic lesions were observed throughout the aorta, especially in the aortic arch. Basal femoral arterial pressure was not significantly different between JW and TGH rabbits. However, the basal pulse pressure in TGH rabbits (48.3  4.5 mmHg) was significantly greater than that of JW rabbits (28.0  5.6 mmHg). Intravenous infusion of NG-nitro-l-arginine methyl ester (l-NAME; 26.9 mg/kg) increased the blood pressure of TGH and JW rabbits. There was no significant difference in the response tol-NAME between the two rabbit strains.



The present study shows that severe atherosclerotic changes develop in TGH rabbits and suggests that the hyperlipidaemia combined with hypercholesterolaemia and hypertriglyceridaemia is an important factor for promoting atherosclerosis in TGH rabbits. The greater pulse pressure in TGH rabbits may be due to the increased vascular stiffness with atherosclerosis.



This newly developed TGH rabbit line of heritable hypertriglyceridaemia with hypercholesterolaemia will become a useful animal model for studies on the role of hyperlipidaemia in the progression of atherosclerosis and in many atherosclerosis-related diseases.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: arterial blood pressure; atherosclerosis; cholesterol; combined hyperlipidaemia; hypertriglyceridaemia; nitric oxide; pulse pressure; rabbit; triglyceride

Document Type: Research Article

Publication date: March 1, 2006

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more