@article {Barun:2005:0305-1870:702,
title = "EFFECTS OF CANNABINOID RECEPTOR ACTIVATION ON RABBIT BISECTED VAS DEFERENS STRIPS",
journal = "Clinical and Experimental Pharmacology and Physiology",
parent_itemid = "infobike://bsc/cep",
publishercode ="bp",
year = "2005",
volume = "32",
number = "9",
publication date ="2005-09-01T00:00:00",
pages = "702-707",
itemtype = "ARTICLE",
issn = "0305-1870",
eissn = "1440-1681",
url = "https://www.ingentaconnect.com/content/bsc/cep/2005/00000032/00000009/art00003",
doi = "doi:10.1111/j.1440-1681.2005.04261.x",
keyword = "AM 251, AM 630, rabbit, anandamide, CB2 receptor, CB1 receptor, bisected vas deferens, WIN 55, 212-2, cannabinoids",
author = "Barun, S{\"u}reyya and Vural, Ismail Mert and Dilek{\"o}z, Ergin and Ercan, Zeynep Sevim and Sarioglu, Yusuf",
abstract = "SUMMARY 1.In the present study, the effects of anandamide and WIN55,212-2, cannabinoid receptor agonists, were investigated on electrical field stimulation (EFS)-induced biphasic twitch responses obtained from the epididymal and prostatic portions of rabbit vas deferens strips.2.Anandamide and WIN55,212-2 dose-dependently inhibited both the first and second phases of the EFS-induced twitch responses recorded from epididymal and prostatic portions of the vas deferens over the concentration range 109to3\texttimes106mol/L. 3.The cannabinoid CB1 receptor antagonist AM251 (106mol/L) and the cannabinoid CB2 receptor antagonist AM630 (106mol/L) had no effect on the inhibitory action of anandamide on the biphasic twitch responses in the prostatic and epididymal portions of the rabbit vas deferens. 4.In both the prostatic and epididymal portions of the rabbit vas deferens, AM251 significantly, but not completely, reversed the inhibitory effect of WIN55,212-2 on the first phase of the twitch response. In contrast, AM630 did not have any effect on the inhibitory action of WIN55,212-2 in the rabbit vas deferens strips.5.The inhibitory effects of anandamide or WIN55,212-2 on EFS-induced twitch responses of both the prostatic and epididymal portions of the rabbit vas deferens were not altered in the presence of 105mol/L naloxone. 6.These results suggest that cannabinoid receptors may have a modulatory role in the regulation of sympathetic transmission in the rabbit vas deferens. However, further investigation is required to characterize the receptors involved.",
}