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EFFECT OF GLYCINE ON TISSUE FATTY ACID COMPOSITION IN AN EXPERIMENTAL MODEL OF ALCOHOL-INDUCED HEPATOTOXICITY

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SUMMARY

1. The aim of the present study was to investigate the effect of the administration of glycine, a non-essential amino acid, on blood alcohol levels and tissue fatty acid composition in experimental rats.

2. Liver cell damage was induced by the administration of ethanol (7.9 g/kg bodyweight) for 30 days by intragastric intubation. Control rats were given isocaloric glucose solution. Glycine was subsequently administered at a dose of 0.6 g/kg bodyweight every day by intragastric intubation for the next 30 days.

3. Feeding alcohol significantly elevated the activities of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatases (ALP) and γ-glutamyl transpeptidase (GGT) and altered the liver and brain fatty acid composition compared with control rats. Subsequently, glycine supplementation to alcohol-fed rats significantly lowered the activities of serum AST, ALT, ALP, GGT and normalized the liver and brain fatty acid composition compared with untreated alcohol-fed rats.

4. Thus, the present study demonstrates that oral administration of glycine confers a significant protective effect against alcohol-induced hepatotoxicity by virtue of its ability to optimize the activities of serum AST, ALT, ALP and GGT, as well as the tissue fatty acid composition.
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Keywords: blood alcohol; ethanol; free fatty acid composition; glycine

Document Type: Research Article

Affiliations: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India

Publication date: July 1, 2004

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