Skip to main content
padlock icon - secure page this page is secure

Analgesic duration and kinetics of liposomal bupivacaine after subcutaneous injection in mice

Buy Article:

$52.00 + tax (Refund Policy)


1. The objective of the present study was to assess the time-course profile of analgesia and bupivacaine concentrations at the site of injection after subcutaneous administration of a single dose of standard bupivacaine or a novel controlled-release liposomal bupivacaine formulation.

2. Groups of mice were injected subcutaneously with 0.2 mL of 0.5% standard bupivacaine or 0.5, 1 or 2% liposomal bupivacaine.

3. A prolonged duration of analgesia occurred in mice receiving liposomal bupivacaine. In the liposomal groups, the bupivacaine remained at the injection site for more than 96 h, compared with approximately 8 h in groups injected with standard bupivacaine.

4. These results confirm that the prolonged analgesia observed after injection of the liposomal formulation is associated with sustained higher levels of bupivacaine at the site of injection.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: analgesia; bupivacaine; kinetics; liposome; mice; pain

Document Type: Short Communication

Affiliations: Department of Anaesthesiology, New York University School of Medicine, New York, New York, USA

Publication date: December 1, 2003

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more