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Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats

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Summary

1. The effects of edible oyster mushroom Pleurotus ostreatus on plasma and liver lipid profiles and on the plasma total anti-oxidant status were estimated in hyper- and normocholesterolaemic Long Evans rats.

2. The feeding of 5% powder of the fruiting bodies of P. ostreatus mushrooms to hypercholesterolaemic rats reduced their plasma total cholesterol by approximately 28%, low-density lipoprotein–cholesterol by approximately 55%, triglyceride by approximately 34%, non-esterified fatty acid by approximately 30% and total liver cholesterol levels by > 34%, with a concurrent increase in plasma high-density lipoprotein–cholesterol concentration of > 21%. However, these effects were not observed in mushroom-fed normocholesterolaemic rats.

3. Mushroom feeding significantly increased plasma fatty acid unsaturation in both normo- and hypercholesterolaemic rats.

4. Plasma total anti-oxidant status, as estimated by the oxidation of 2,2′-azino-bis-[3-ethylbenz-thiazoline-6-sulphonic-acid], was significantly decreased in mushroom-fed hypercholesterolaemic rats, concomitant with a decrease in plasma total cholesterol.

5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.
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Keywords: Pleurotus ostreatus; atherogenic lipid profile; hypercholesterolaemia; total anti-oxidant status; unsaturation index

Document Type: Research Article

Affiliations: 1: Department of Physiology, Shimane Medical University, Shimane, Japan, Departments of 2: Department of Biochemistry & Molecular Biology, University of Dhaka, 3: Botany and 4: International Center for Diarrheal Diseases and Research and 5: Center for Scientific and Industrial Research, Dhaka, Bangladesh 6: Pharmacy, Jahangirnagar University,

Publication date: July 1, 2003

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