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Effect Of Kad-1229, A Novel Hypoglycaemic Agent, On Plasma Glucose Levels After Meal Load In Type 2 Diabetic Rats

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SUMMARY

1. The effects of KAD-1229 (a novel non-sulphonylurea agent), voglibose (an α-glucosidase inhibitor) and nateglinide (a non-sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats.

2. KAD-1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load.

3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUCglucose following voglibose was not observed.

4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUCglucose was not decreased.

5. The results indicate that KAD-1229 has an antihyperglycaemic effect and KAD-1229 is suggested to be a suitable agent for controlling post-prandial hyperglycaemia.
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Keywords: KAD-1229; meal load; nateglinide; plasma glucose level; plasma insulin; rats; type 2 diabetes; voglibose

Document Type: Research Article

Affiliations: Pharmacology Laboratories, Kissei Pharmaceutical Co. Ltd, Hotaka, Nagano, Japan

Publication date: May 1, 2002

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