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Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score

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Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid‐treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual‐energy X‐ray absorptiometry acquisitions. Our aim was to compare vertebral BMD and TBS in patients with overt CS and mild autonomous cortisol secretion (MACE), and following cure of overt CS.
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Keywords: Cushing's syndrome; adrenal incidentaloma; bone microarchitecture; bone mineral density; osteoporosis; subclinical hypercortisolism; trabecular bone score

Document Type: Research Article

Publication date: August 1, 2018

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