Skip to main content
padlock icon - secure page this page is secure

Bone turnover markers predict changes in bone mineral density after parathyroidectomy in patients with renal hyperparathyroidism

Buy Article:

$59.00 + tax (Refund Policy)

Summary

Objective  Patients on long‐term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX.

Design and patients  Renal patients on maintenance haemodialysis who received PTX for refractory SHPT (n = 26, male/female: 13/13; mean age: 48·6 ± 10·7 year) and control subjects without SHPT (n = 25) were prospectively followed for 1 year at two tertiary hospitals in Taiwan.

Measurements  Serum intact parathyroid hormone (iPTH), bone‐specific alkaline phosphatase (BAP) and type 5b tartrate‐resistant acid phosphatase (TRAP) were measured serially. Additionally, femoral neck (FN) and lumbar spine (LS) BMD were measured before and 1 year after PTX.

Results  After PTX, iPTH levels decreased markedly and persistently. BMDs increased in both the FN and LS, but particularly in the LS. Serum BAP progressively increased to a peak at 2 weeks after PTX. Serum TRAP levels progressively decreased over 6 months after PTX. In univariate correlation analyses, baseline iPTH correlated positively with T‐score changes in FN (r = 0·45, P =0·021) and LS (r = 0·48, P =0·013). In multivariate regression models, changes in FN T‐scores were negatively predicted by baseline BAP levels (r = −0·615, P =0·005) and baseline FN T‐scores (r = −0·563, P =0·012), and they were positively predicted by baseline TRAP(r = 0·6, P =0·007). Changes in LS T‐scores were positively predicted by baseline TRAP values (r = 0·528, P =0·01) and negatively predicted by the percentage change in BAP after 2 weeks (r = −0·501, P =0·015).

Conclusions  Parathyroidectomy provided marked, sustained improvements in BMD for up to 1 year. Furthermore, markers of bone turnover predicted 1‐year changes in FN and LS BMDs after PTX.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Division of Nephrology 2: Division of Endocrinology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan 3: Department of Surgery 4: Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Publication date: May 1, 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more