Plasma dehydroepiandrosterone sulphate and insulin‐like growth factor I levels in obstructive sleep apnoea syndrome
Context We aimed to assess whether obstructive sleep apnoea syndrome (OSAS) affects plasma IGF‐1 and dehydroepiandrosterone sulphate (DHEA‐S) levels in men, factors implicated in the development of age‐related metabolic disorders.
Design We conducted a cross‐sectional and longitudinal clinical study.
Patients and setting We measured plasma IGF‐1 and DHEA‐S levels in 191 non–drug‐treated Japanese men (34 primary snorers (PS), 88 patients with mild‐to‐moderate OSAS and 69 patients severe OSAS ).
Results Plasma IGF‐1 and DHEA‐S were negatively correlated with age. Plasma IGF‐1 was also negatively correlated with plasma glucose, HOMA‐IR and systolic blood pressure and apnoea parameters such as the apnoea–hypopnea index, minimum oxygen saturation and slow‐wave sleep (SWS) time. Plasma DHEA‐S was associated with plasma glucose, HbA1c and free fatty acid and was negatively correlated with SWS time. To eliminate the influence of age, PS, patients with mild‐to‐moderate OSAS and severe OSAS were divided into three groups by age: young (<40 years), middle‐aged (40–59 years) and elderly (≥60 years). Patients with severe OSAS aged <40 or <60 years had lower plasma IGF‐1 or DHEA‐S levels, respectively, than did the corresponding snorers and mild‐to‐moderate OSAS groups. Continuous positive airway pressure therapy for generally 16–18 months increased plasma IGF‐1 levels in patients with severe OSAS aged <40 years (n = 18). Plasma DHEA‐S levels were increased in patients with severe OSAS aged <60 years, whose DHEA‐S level was below the mean value for that age (n = 23/41).
Conclusion Severe OSAS could reduce plasma IGF‐1 and DHEA‐S levels in younger, but not elderly Japanese men, which is potentially associated with the development of metabolic abnormalities.
Document Type: Research Article
Affiliations: 1: Departments of Internal Medicine 2: Respiratory Therapy, Osaka Gyomeikan Hospital, Kasugade-naka, Konohana-ku, Osaka 3: Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Okoh-cho, Nankoku, Kochi, Japan
Publication date: April 1, 2012