Skip to main content
padlock icon - secure page this page is secure

The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men

Buy Article:

$59.00 + tax (Refund Policy)

Summary Objective 

Although osteoporosis is increasingly shown to occur in a considerable proportion of men, data on risk factors for male osteoporosis are limited. In this study, we investigated the association between serum thyrotropin (TSH) concentration and bone mineral density (BMD) in healthy euthyroid men. Design 

A cross-sectional community (health promotion centre)-based survey. Subjects and measurements 

For 1478 apparently healthy euthyroid men who participated in a routine health screening examination, we measured BMD at the lumbar spine and femoral neck using dual energy X-ray absorptiometry and serum TSH concentrations using immunoluminometry. Results 

Lumbar spine BMD linearly increased with TSH level after adjustment for age, weight and height (P for trend = 0·002), and statistical significance persisted after additional adjustment for smoking and drinking habits (P for trend = 0·010). When serum alkaline phosphatase was added as a confounding variable, the relationship was still significant (P for trend = 0·016). Femoral neck BMD also tended to increase in higher TSH concentration after adjustment for age, weight and height (P for trend = 0·042), but this association disappeared after additional adjustment for smoking and drinking habits. The odds of lower BMD (i.e. osteopaenia and osteoporosis combined) were significantly increased in subjects with low-normal TSH (i.e. 0·4–1·2 mU/l), when compared to high-normal TSH (i.e. 3·1–5·0 mU/l), after adjustment for confounding factors (odds ratio = 1·45, 95% CI = 1·02–2·10). Conclusion 

These results suggest that a serum TSH concentration at the lower end of the reference range may be associated with low BMD in men.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Division of Endocrinology and Metabolism 2: Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 3: Division of Endocrinology and Metabolism, Sanbon Medical Center, University of Wonkwang College of Medicine, Iksan, Korea

Publication date: September 1, 2010

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more