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The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects

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Summary Objective: 

To examine the association of serum vitamin D level with metabolic syndrome (MetS) and hypertension (HTN) in middle-aged Korean subjects. Design and subjects: 

We conducted a population-based, cross-sectional survey of 1330 participants aged over 40 years (median age 65·8 years) in Chungju, Korea, in 2007. The 324 subjects, who were normotensive in 2003 and who attended a follow-up visit 4 years later, were included in an analysis of the association of serum vitamin D level with the risk of HTN. Measurements: 

Serum 25-hydroxy-vitamin D [25(OH)D] and PTH were measured in a central laboratory, using chemiluminescence assays. Results: 

The overall prevalence of the MetS in participants of this study was 45·3%. After adjusting for various covariates, subjects in the highest quintile group (61·4–116·8 nmol/l) compared with the lowest quintile group (10·0–29·7 nmol/l) of 25(OH)D had an odds ratio (OR) for having MetS of 0·35 (95% confidence intervals, CI, 0·22–0·56; P for trend <0·001). The median level of 25(OH)D was 46·8 nmol/l among 324 subjects who were normotensive in 2003. After multiple adjustment, the OR was substantially higher for new HTN (OR 2·74; 95% CI 1·40–5·34) in subjects with serum 25(OH)D levels below the median value compared with those above median. The inverse associations of vitamin D and MetS/HTN were unchanged after adjustment for PTH and serum calcium levels. There was no association between PTH and MetS. Conclusions: 

We found a strong inverse association of 25(OH)D levels with MetS and HTN in this middle-aged Korean population. Having vitamin D deficiency was associated with an increased risk of having MetS and HTN in this demographic group.
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Document Type: Research Article

Affiliations: 1: Department of Internal Medicine, The Catholic University of Korea 2: Department of Internal Medicine, Sungkyunkwan University School of Medicine 3: Department of Preventive Medicine, The Catholic University of Korea, Seoul, Korea

Publication date: September 1, 2010

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