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Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)

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Summary Objective 

To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT). Design 

Retrospective population-based observational study. Setting 

Tayside, Scotland, from 1997 to 2006. Participants 

Patients with mild PHPT were selected from a predefined PHPT cohort between 1997 and 2006. Main outcome measures 

Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities. Results 

In total, there were 1683 (69·1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2·62, 95% CI 2·39–2·86; SMR-cardiovascular 2·68, 95% CI 2·34–3·05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population. Conclusions 

Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.
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Document Type: Research Article

Affiliations: 1: Dundee Epidemiology and Biostatistics Unit, Division of Clinical & Population Sciences & Education 2: Cardiovascular & Lung Biology, Medical Sciences, School of Medicine 3: Academic Clinical Practice, Division of Clinical & Population Sciences & Education 4: Department of Surgery 5: School of Medicine 6: Biomedical Research Institute, School of Medicine, University of Dundee, Scotland, UK

Publication date: July 1, 2010

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