Skip to main content
padlock icon - secure page this page is secure

Neuroendocrine response to supine posture in healthy children and patients with nocturnal enuresis

Buy Article:

$52.00 + tax (Refund Policy)

Summary Objective 

To elucidate the background behind the attenuated circadian rhythm of vasoactive hormones in patients with nocturnal enuresis, we tested the hypothesis that enuretic children exhibit an abnormal neuroendocrine response to a baroreflex stimulus during daytime. Design and patients 

In fifteen children and adolescents (aged 13·4 ± 0·9 years) with severe nocturnal enuresis and 10 age- and sex-matched healthy controls, we performed a ‘daytime supine posture’ (DSP) study at 10:00 h. Measurements 

Blood was sampled for measurements of plasma vasopressin (PAVP), angiotensin II (PANGII), atrial natriuretic peptide (PANP) and serum aldosterone (SALDO), and mean arterial blood pressure (MAP) and heart rate (HR) were measured during the study. Results 

In both controls and patients with enuresis, DSP at 10:00 h resulted in a marked fall in MAP and HR, a rise in pulse pressure (PP) and estimated plasma volume (PV) and a significant suppression of PAVP, PANGII and SALDO, whereas PANP increased. There were no significant differences between groups in haemodynamic or neuroendocrine responses to DSP. Conclusions 

The study showed that children with nocturnal enuresis exhibit a normal neuroendocrine response to supine posture during daytime indicating that baroregulatory mechanisms per se are not playing a significant pathogenic role. Interestingly, the normal neuroendocrine response to supine posture seems to undergo marked circadian changes, as supine posture at night-time is associated with increased levels of vasoactive hormones.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: June 1, 2010

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more