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Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndrome

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Summary Objective 

To compare the efficacy of clomiphene citrate (CC) administration for ovulation induction in CC-resistant oligo-ovulatory women with polycystic ovary syndrome (PCOS) after metformin treatment or laparoscopic ovarian drilling (LOD). Design 

Prospective controlled study. Patients 

Twenty-eight overweight oligo-amenorrhoeic women with PCOS who were still anovulatory after metformin administration (group A, n = 8) or LOD (group B, n = 20). Methods 

Treatment with CC 150 mg/day for 5 days from the third to the seventh day of a progesterone-induced uterine bleeding for 6 months. Measurements 

The ovulation, pregnancy, abortion and live-birth rates were evaluated in each group. Results 

The subjects of groups A and B were studied for a total of 36 and 74 cycles, respectively. At the end of the study, no differences in ovulation [11/36 (30·6%) vs. 23/74 (31·1%); P = 0·96], pregnancy [6/36 (16·7%) vs. 12/74 (16·2%); P = 0·95], abortion [2/6 (33·3%) vs. 5/12 (41·7%); P = 1·00] and the live-birth [4/6 (66·7%) vs. 7/12 (58·3%); P = 1·00] rates were observed between groups A and B. Conclusion 

Metformin administration as well as LOD improves the effectiveness of CC for ovulation induction in overweight infertile CC-resistant women with PCOS.
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Document Type: Research Article

Affiliations: 1: Department of Obstetrics and Gynaecology, University ‘Magna Graecia’ of Catanzaro and Departments of 2: Molecular and Clinical Endocrinology and Oncology, 3: Clinical and Experimental Medicine and 4: Obstetrics and Gynaecology, University ‘Federico II’ of Naples, Italy

Publication date: December 1, 2005

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