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Effects of recombinant LH (rLH) supplementation during controlled ovarian hyperstimulation (COH) in normogonadotrophic women with an initial inadequate response to recombinant FSH (rFSH) after pituitary downregulation

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Summary background 

This study was aimed to evaluate the effect of different recombinant LH (rLH) doses on the ovarian outcome of normogonadotrophic women with an initial inadequate response to recombinant FSH (rFSH) after pituitary downregulation. methods 

Only women undergoing a ‘long protocol’ with a GnRH-agonist followed by rFSH administration were enrolled. On the eighth day of stimulation, 46 patients with serum E2 levels < 180 pg/ml and with no follicle > 10 mm were randomized in two groups to receive a supplementation with a daily rLH dose of 75 (group A) or 150 IU (group B), respectively. Forty-six normal responders continuing their monotherapy with rFSH formed the control group (C). results 

The mean number of oocytes retrieved and the percentage of mature oocytes in the group B (9·65 ± 2·16, 79·0%) were comparable with those observed in the group C (10·65 ± 2·8, 82·5%) and significantly higher when compared with the group A (6·39 ± 1·53, 65·7%). The mean number of ampoules of rLH was significantly higher in the group B (14·4 ± 2·0 vs. 9·65 ± 1·1), whereas these patients received a significantly lower mean number of rFSH ampoules (44·6 ± 7·4 vs. 36·1 ± 3·8). Seven (30·4%), 9 (39·1%) and 22 (47·8%) pregnancies were achieved in the groups A, B and C, respectively. conclusions 

These results suggest that patients with initial inadequate responses to rFSH after pituitary downregulation benefit from the addition of a daily dose of 150 IU of rLH, starting from the eighth day of stimulation.
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Document Type: Research Article

Affiliations: 1: Dipartimento Universitario di Scienze Ostetriche Ginecologiche e Medicina della Riproduzione, Area Funzionale di Medicina della Riproduzione ed Endoscopia Ginecologica, Università degli Studi di Napoli ‘Federico II’, 2: Centre for Reproductive Biology, Clinica Villa del Sole and 3: Dipartimento Universitario di Scienze Ginecologiche, Ostetriche e della Riproduzione, II Università di Napoli, Naples, Italy

Publication date: May 1, 2004

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