Skip to main content
padlock icon - secure page this page is secure

Earlier initiation of GH therapy does not influence adult height but enables earlier start of pubertal induction in children with multiple pituitary hormone deficiency

Buy Article:

$52.00 + tax (Refund Policy)

Summary objective 

For patients with GH and gonadotrophin deficiency, adult height and sexual maturation are important not only for their physical but also psychological status. GH therapy is usually initiated soon after diagnosis but the differences in the age for initiation of therapy have not been previously examined. In this study, we assessed the influence of timing of initiation of GH therapy on adult height and the time of initiation of pubertal induction. design, patients and measurements 

Height-related data from 16 short children (13 boys and three girls) with GH and gonadotrophin deficiency who reached adult height after 10·9 ± 2·3 years of GH therapy were analysed retrospectively. results 

Adult height (0·00 ± 0·69 SD) improved remarkably compared to height SDS at the start of GH therapy (−3·75 ± 0·94 SD). The age at which GH therapy was started ranged from 3·2 to 12·0 years, but we found that such a difference in age did not affect adult height. However, an earlier start of GH therapy allowed earlier pubertal induction without loss of height potential. conclusions 

Earlier initiation of GH therapy is not required for normalization of adult height in patients with GH and gonadotrophin deficiency but it makes earlier pubertal induction possible, which is important for quality of life.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Pediatrics, Faculty of Medicine, Kyoto University, Kyoto and 2: Department of Pediatrics, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan

Publication date: May 1, 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more