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First trimester levels of inhibins and activin A in normal and failing pregnancies

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Summary objective 

Miscarriage is the commonest complication of human pregnancy. We undertook this study to assess whether inhibin A, pro-αC inhibin and/or activin A, products of the corpus luteum and placenta, might be useful in either the prediction or diagnosis of miscarriage. design 

Case–control study. patients 

Ninety-eight asymptomatic women at 6–13 weeks gestation who subsequently had a miscarriage and 198 gestation-matched women with a normal singleton pregnancy. measurements 

Maternal serum levels of inhibin A, pro-αC inhibin, activin A and human chorionic gonadotrophin (hCG) were measured. results 

Inhibin A, pro-αC and hCG, expressed as multiples of the normal median (MoM; ±95% confidence intervals) in the miscarriage cases were significantly lower than in the viable controls, 0·56 (0·48–0·69) MoM vs. 1·00 (0·98–1·13) MoM, 0·55 (0·51–0·84) MoM vs. 1·0 (0·86–1·22) MoM and 0·34 (0·23–0·36) MoM vs. 1·00 (0·94–1·08) MoM, respectively (P < 0·0001 for all). Of the three analytes, hCG was the most discriminating between cases and controls. Levels of activin A in the miscarriage cases were not significantly different from controls, 0·96 (0·86–1·07) vs. 1·0 (0·95–1·08). conclusions 

These data suggest that inhibin A, pro-αC inhibin and activin A will not be useful in either the prediction or diagnosis of early pregnancy miscarriage.
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Document Type: Research Article

Affiliations: Centre for Women's Health Research, Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, Victoria, Australia

Publication date: April 1, 2004

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