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Left ventricular mass index and ventricular septum thickness are associated with serum dehydroepiandrosterone-sulphate levels in hypertensive women

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Summary objective

 Several data indicate that endogenous sex steroids might influence left ventricular mass. Our aim was to examine the association between dehyroepiandrosterone-sulphate (DHEAS) levels and left ventricular mass index (LVMI) and ventricular septal thickness (VST) in pre- and in postmenopausal women with treated essential hypertension. patients and methods

 LVMI and VST were related to serum DHEAS in 26 pre- and in 34 postmenopausal women. The associations between DHEAS and LVMI, VST were adjusted for body mass index, duration of hypertension, systolic blood pressure, serum cholesterol and testosterone levels using a multiple regression model. results

 In premenopausal women there was a significant linear correlation between DHEAS and LVMI (P < 0·02) after adjustment for confounding variables. In contrast, DHEAS was inversely correlated with LVMI and VST in postmenopausal women (r = −0·49, P < 0·02, r =−0·42, P < 0·02, respectively). These associations also remained significant (P = 0·04, P = 0·03, respectively) after adjustment for confounding variables. conclusion

 DHEAS might be an independent determinant of LVMI and VST. Its effect on the heart may depend on hormonal milieu. In premenopausal women, DHEAS might have androgenic effects and might enhance fibroblast proliferation; while during the postmenopausal period it is dominantly oestrogenic in action, with antiproliferative effect on cardiac cells.
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Document Type: Research Article

Affiliations: 1: First Department of Medicine and 2: Joint Research Programme of First Department of Pediatrics and Hungarian Academy of Sciences, Semmelweis University Budapest, Hungary

Publication date: July 1, 2003

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