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Malignant human renin producing paraganglionoma–localization with 123I-MIBG and treatment with 131I-MIBG

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A 22-year-old woman presenting severe hypertension and hypokalaemia is described. Initial evaluation showed a large tumour localized at the position of the left adrenal gland. Subsequent surgery temporarily relieved all signs and symptoms caused by the tumour. The symptoms relapsed after a 2-year disease-free interval. At re-evaluation, the tumour was shown to produce an uncontrolled secretion of renin, thus triggering aldosterone-dependent hypertension. This report describes the diagnosis, treatment and clinical course of this unique patient with a malignant paraganglionoma of adrenal origin.
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Document Type: Research Article

Affiliations: 1: Endocrinology and Diabetology, 2: Diagnostic Radiology, Division of Nuclear Medicine, 3: Surgery, 4: Oncology, Karolinska Hospital Stockholm, 5: Deparment of Pathology, University Hospital, Uppsala, Sweden

Publication date: November 1, 1999

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