Skip to main content
padlock icon - secure page this page is secure

Growth hormone treatment improves body fluid distribution in patients undergoing elective abdominal surgery

Buy Article:

$59.00 + tax (Refund Policy)


To investigate the possible beneficial effects of growth hormone (GH) in catabolic patients we examined the impact of GH on body fluid distribution in patients with ulcerative colitis undergoing elective abdominal surgery. DESIGN AND MEASUREMENTS

Twenty-four patients (14 female, 10 male) aged 19–47 years were in a double-blinded study randomly assigned to receive either placebo (n = 12) or GH (n = 12) 6IU s.c. twice daily from 2 days before until 7 days after ileo-anal J pouch surgery. Extracellular and plasma volume (ECV, PV) were determined using 82Br and 125I albumin dilution at day −2 and at day 7, and body composition was estimated by dual X-ray absorptiometry and bioimpedance. Changes in body weight and fluid balance were recorded and hence intracellular volume was assessed. RESULTS

During placebo treatment body weight decreased 4.3± 0.6 kg; during GH treatment body weight was constant (P < 0.01). There was a positive fluid balance in the GH-treated patients compared to the placebo group (GH: 3.6 ± 0.7 l; plc: −0.7 ± 1.2 l, P < 0.01). ECV increased 2.12 ± 0.70 l during GH and was unaffected during placebo (P = 0.02). PV was unchanged by GH and decreased 0.39 ± 0.08 l during placebo administration (P = 0.03). Intracellular volume (ICV) decreased less during GH than during placebo (GH: −1.42 ± 0.45; plc: −3.70 ± 0.76; P = 0.02). Bioimpedance remained constant during GH administration and increased 60 ± 9 ohm in the placebo-treated group (P < 0.05). Plasma renin and aldosterone remained unchanged in both study groups. CONCLUSION

Body weight, plasma volume and intracellular volume is preserved during GH treatment in catabolic patients and ECV is increased. From a therapeutic point of view these effects may be desirable under conditions of surgical stress.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Original Article

Affiliations: 1: Medical Department M, Aarhus University Hospital, Aarhus C, 2: Department of Surgery L, Aarhus University Hospital, Aarhus C, 3: Department of Clinical Physiology, Københavns Amtssygehus Glostrup, Denmark

Publication date: November 1, 1998

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more