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DT56a (Femarelle) stimulates bone formation in female rats

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DT56a is a natural compound for the treatment of menopausal symptoms and osteoporosis. The aim of this study was to examine the effects of long term treatment (two months) with DT56a on the skeletal tissues of intact and ovariectomised (OVX) adult rats. Design 

Thirty rats were divided into two groups, in one of which the rats were ovariectomised. The rats in each group were then treated for two months with DT56a, oestrogen or vehicle. Setting 

University and hospital laboratories. Population 

Thirty rats. Methods 

Histomorphometric measurements of trabecular bone volume (expressed as a percentage of total bone volume), trabecular and cortical thickness and growth plate width were recorded by a computerised system. In addition, creatine kinase (CK)-specific activity, as marker of oestrogen receptor activation, was measured in skeletal tissues and in the uterus. Main outcome measures 

The changes in the histomorphometric measurements. Results 

OVX rats developed noticeable signs of osteoporosis, namely, significant decrease in trabecular bone volume and in trabecular and cortical thickness. DT56a, like oestrogen, restored the bone structure measurements of all tested parameters in the OVX rats to the values obtained in the intact rats. In skeletal tissues, CK activity was elevated in both treatment groups. However, in the uterus DT56a did not activate oestrogen receptors while oestrogen did elevate CK activity. Conclusions 

DT56a was as effective as oestrogen in reversing the bone changes caused by OVX in rats.
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Document Type: Research Article

Affiliations: 1: Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Israel 2: Department of Anatomy, Rambam Medical Center, Haifa, Israel 3: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

Publication date: 01 July 2005

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