Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?
Elevated levels of C-reactive protein (CRP) were found recently to be a crucial marker for cardiovascular disease. This protein might have a role in endothelial cell activation, vascular damage and a thrombotic tendency. We sought to determine whether concentrations of CRP are altered in women with controlled ovarian hyperstimulation (COH) or hyperstimulation syndrome (OHSS). Design
A prospective cohort study. Setting
The gynecology department and IVF unit of the Lis maternity hospital. Population
Twenty women with OHSS, 20 women undergoing COH and 20 women who participated as controls were included in the study. Methods
Venous blood was withdrawn for analysis of high sensitive C-reactive protein (hs-CRP) using the Boering BN-II nephelometer. Main outcome measures
hs-CRP levels were determined. Results
There was a significant (P < 0.05) difference in the hs-CRP concentrations in women with OHSS compared with women with COH and controls. The respective values for hs-CRP were 19.0 [4.0], 7.0 [1.7] and 4.6 [1.1] mg/L. Conclusions
Women with OHSS have elevated concentrations of hs-CRP. This finding, previously believed to merely represent an acute phase response, may actually represent a yet unrecognised pathophysiological factor of this syndrome and pave the way for new investigational directions of this potentially hazardous condition.
Document Type: Research Article
Affiliations: 1: Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel 2: Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
Publication date: 01 July 2005