Skip to main content
padlock icon - secure page this page is secure

Plasma levels of opioid peptides after sunbed exposures

Buy Article:

$52.00 + tax (Refund Policy)

Summary

Background  Previous studies have indicated that solar and artificial ultraviolet (UV) radiation have a positive influence on psychological variables such as mood and emotional state. Circulating opioid peptides have been suggested as being important in this effect.

Objectives  To investigate in a controlled trial the influence of UVA radiation on opioid peptide levels.

Methods  We determined plasma levels of β-endorphin immunoreactive material (IRM) and met-enkephalin in UV-exposed (n = 35) and non-exposed (n = 9) healthy volunteers. On the first day of the study, blood samples were taken from the volunteers (time A). UVA irradiation was subsequently administered with an air-conditioned tanning device. During the UV exposures the volunteers wore opaque goggles. Twenty minutes after UV exposure, blood samples were collected again (time B). Within the following 3 weeks the volunteers had a series of five UV exposures. On the last day of the study (24 h after the sixth UV exposure) blood samples were collected (time C). The cumulative UVA doses were 96 J cm−2 for skin type II and 126 J cm−2 for skin type III. The controls had no UV exposures. Plasma β-endorphin IRM and met-enkephalin levels were determined using radioimmunoassays.

Results  At all times of blood collection (A, B, C), there were no significant differences in plasma levels of β-endorphin IRM and met-enkephalin between UV-exposed and non-exposed volunteers (P > 0·05).

Conclusions  UVA irradiation does not significantly elevate plasma levels of β-endorphin IRM and met-enkephalin. Therefore we suggest that psychological benefits claimed to occur after UV exposure are unlikely to be mediated by the types of circulating opioid peptides measured in this study.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: met-enkephalin; neuropeptides; proopiomelanocortin; ultraviolet A irradiation; β-endorphin immunoreactive material

Document Type: Research Article

Affiliations: 1: Department of Dermatology, Ruhr-University Bochum, Gudrunstasse 56, D-4479 Bochum, Germany 2: Department of Anaesthesiology and Intensive Care Medicine, Charité University Hospital, Schumannstrasse 20–21, D-10017 Berlin, Germany

Publication date: December 1, 2002

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more