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Cutaneous presentation of steroid responsive blastoid natural killer cell lymphoma

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CD56+ lymphomas derived from natural killer (NK) cell lineage are rarely encountered in Western populations and their clinical and pathological features have not been fully defined. The majority of reported cases are lymphomas of the nasal cavity, which are most commonly seen in Asia. A subtype of CD56+ lymphoma has recently been described (blastoid NK-cell lymphoma) which characteristically presents in older patients with cutaneous infiltrates and disease at other nodal and extranodal sites. We describe a case that correlates well with the clinicopathological features of blastoid NK-cell lymphoma. An unusual feature in our patient was that the cutaneous features of the lymphoma showed complete resolution shortly following commencement of oral steroid therapy.
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Keywords: CD56; cutaneous lymphoma; immunohistochemistry; lymphoma; natural killer cell

Document Type: Research Article

Affiliations: 1: Departments of Dermatology, 2: Haematology and 3: Histopathology, Bristol Royal Infirmary, Bristol BS2 8HW, U.K.

Publication date: May 1, 2000

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