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Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel

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Docetaxel (Taxotere®), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.
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Keywords: Taxotere®; adverse drug reaction; docetaxel; erythrodysaesthesia

Document Type: Research Article

Affiliations: 1: Departments of Dermatology and 2: Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan

Publication date: April 1, 2000

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