A synthetic intermediate of enantiopure N-protected -hydroxyvaline, (2R)-2-[N-(tert-butoxycarbonyl)amino]-3-methylbutane-1,3-diol
Crystals of the title compound [systematic name: (2R)-tert-butyl N-(1,3-dihydroxy-3-methyl-2-butyl)carbamate], C10H21NO4, were successfully grown from an ethyl acetate solution. There is one independent molecule in the asymmetric unit. The urethane linkage, –O—CO—NH–, is a cis conformer and the molecules are linked into a dimer by two N—H…O=C hydrogen bonds. The dimers are connected together by O—H…O hydrogen bonds in which four hydroxy groups are involved.
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Document Type: Research Article
Publication date: December 1, 2004