The title compound, C19H22NClO3, was synthesized by an intramolecular condensation reaction of N-[2-hydroxy-2-(methoxyphenyl)ethyl]-2-(2-chloro-3,4-dimethoxyphenyl)ethylamine in trifluoroacetic acid with 36 N H2SO4 at room temperature and obtained in 69% yield. The crystal structure determined by X-ray diffraction shows normal bond lengths and angles. The seven-membered ring adopts a half-chair conformation.
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Document Type: Research Article
Publication date: December 1, 2004