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Influence of estrogen on acetylcholinesterase activity in primary cultures of cerebral cells from neonatal rats

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To estimate the influence of estrogen on the functional development of the central nervous system during the neonatal period, several doses of estradiol-17β (E2) were treated to cultured cells from the cerebral cortex of neonatal rats and the acetylcholinesterase (AChE) activity was examined. E2 was added to give the following final concentrations: 0, 10−10, 10−9, and 10−8 M. After 72 h of incubation, all cells were obtained from dishes to determine the AChE activity. Although apparent morphological changes were not observed among treatments cultured for 72 h, E2 suppressed dose-dependently the spontaneous increase of AChE activity in cerebral cells. Furthermore, a single dose of tamoxifen, an E2 receptor binding molecule with agonist and antagonist properties, also acted in a similar manner as E2. These findings suggest that the functional development of the cerebral cortex, at least the cholinergic system, during the neonatal period is regulated by E2.
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Keywords: acetylcholinesterase; cerebral cortex; estrogen; neonatal rats

Document Type: Research Article

Affiliations: College of Bioresource Sciences, Nihon University, Fujisawa-shi, Japan

Publication date: February 1, 2004

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