Skip to main content
padlock icon - secure page this page is secure

Viability of maternally heat-stressed mouse zygotes in vivo and in vitro

Buy Article:

$52.00 + tax (Refund Policy)


Mammalian preimplantation embryos are susceptible to heat stress. This present study examined how maternal heat stress affects the development of mouse zygotes in vivo and in vitro. In Experiment 1, zygotes collected from female mice that were heat-stressed for 12 h on day 1 of pregnancy were cultured in vitro. Maternally heat-stressed zygotes developed normally to the two-cell stage, but the majority of embryos failed to develop into morulae or blastocysts. In Experiment 2, pregnant mice were heat-stressed on day 1 or from day 1 to day 3 of pregnancy. The number of living fetuses on day 14 of pregnancy was lower in heat-stressed mice than in non-stressed mice, but the difference was significant only in successively heat-stressed mice. These results demonstrate that maternally heat-stressed zygotes have reduced in vitro viability, but this phenomenon does not necessarily lead to embryo loss in the maternal environment.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: maternal heat stress; mouse embryo viability; postimplantation; preimplantation

Document Type: Research Article

Affiliations: Institute of Agriculture and Forestry, University of Tsukuba, Tsukuba-shi, Japan

Publication date: June 1, 2003

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more