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Review article: exploring strategies to improve treatment outcomes and compliance in specific patient groups with acid–related disorders

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Summary

Specific patient groups consisting of those with nasogastric or gastrostom feeding tubes such as those with stroke neurological impairment or other etiologies, patients with difficulty swallowing (i.e. oral pharyngeal dysfunction), unconscious patients and children who dislike or refuse taking or cannot swallow tablets require special attention with regard to the pharmacological treatment of acid-related disorders.

In particular, these groups of patients require special formulations in order to achieve optimal compliance with acid suppression therapy. Formulations such as the syrup histamine (H2)-receptor antagonist in a syrup formulation, or for proton pump inhibitors, either the multiple unit pellet capsules, fast dissolving tablets or intravenous formulations, can be used to overcome swallowing problems or bitter taste.
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Document Type: Research Article

Affiliations: 1: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Atlanta, GA, USA 2: Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Shimane, Japan 3: Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan 4: Pediatric GI Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 5: Division of Gastroenterology/Hepatology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand 6: Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Publication date: March 1, 2007

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