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Extracorporeal Membrane Oxygenator Compatible with Centrifugal Blood Pumps

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Coil-type silicone membrane oxygenators can only be used with roller blood pumps due to the resistance from the high blood flow. Therefore, during extracorporeal membrane oxygenation (ECMO) treatment, the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis, which is a serious problem. A silicone rubber, hollow fiber membrane oxygenator that has a low blood flow resistance was developed and evaluated with centrifugal pumps. During in vitro tests, sufficient gas transfer was demonstrated with a blood flow less than 3 L/min. Blood flow resistance was 18 mm Hg at 1 L/min blood flow. This oxygenator module was combined with the Gyro C1E3 (Kyocera, Japan), and veno-arterial ECMO was established on a Dexter strain calf. An ex vivo experiment was performed for 3 days with stable gas performance and low blood flow resistance. The combination of this oxygenator and centrifugal pump may be advantageous to enhance biocompatibility and have less blood trauma characteristics.
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Keywords: Blood compatibility; Centrifugal pumps; Extracorporeal membrane oxygenation; Hemolysis; Silicone hollow fiber

Document Type: Research Article

Affiliations: 1: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; and 2: Fuji Systems Corporation, Yokohama, Japan

Publication date: November 1, 2002

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