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Use of Continuous ECG for Improvements in Assessing the Standing Response as a Positive Control for QT Prolongation

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Standing invoked change in QT interval has been identified as a promising autonomic maneuver for the assessment of QT/QTc prolongation in patients with underlying heart abnormalities or as a positive control in healthy volunteers for drug studies. Criticism for its more widespread use is the high variability in reported results and the need for a more standardized methodology with defined normal ranges.
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Keywords: QTc prolongation; autonomic; hysteresis; positive control; standing

Document Type: Research Article

Publication date: January 1, 2014

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