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Single Nucleotide Polymorphisms in Proximity to K‐Channel Genes Are Associated with Decreased Longitudinal QTc Variance

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Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Despite significant progress in identification of predisposing factors, the pathophysiology of AF remains to be elucidated. Previous studies have reported that single nucleotide polymorphisms (SNPs) in potassium‐channel genes associate with AF and the instantaneous corrected QT interval (QTc). The purpose of this study was to examine the association between SNPs in proximity to KCNQ1, KCNH2, KCNE2, and KCNJ2 and longitudinal QTc variations in patients with AF.
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Keywords: QT interval; atrial fibrillation; gene polymorphism; potassium channels

Document Type: Research Article

Publication date: January 1, 2014

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