Skip to main content
padlock icon - secure page this page is secure

Diagnostic Utility of Signal-Averaged Electrocardiography for Detection of Cardiac Sarcoidosis

Buy Article:

$52.00 + tax (Refund Policy)

Introduction: Cardiac sarcoidosis (CS) occurs in up to 25% of patients with pulmonary involvement. Early diagnosis is critical because sudden death from ventricular arrhythmias can be the initial presentation. We sought to evaluate the diagnostic utility of signal-averaged ECG (SAECG) for detection of cardiac involvement of sarcoidosis.

Methods: Subjects with biopsy proven sarcoidosis and symptoms suggestive of possible cardiac involvement were included in the cohort. Standard criteria for SAECG were used. Subjects were considered to have CS if they met criteria established by the Japanese Ministry of Health and Welfare modified to include cardiac MRI.

Results: Of the 88 patients in the cohort 27 had evidence of CS independent of the SAECG results. The SAECG was abnormal in 14 of these 27 patients and 11 of the 61 of the subjects without cardiac involvement (P < 0.01). The sensitivity of SAECG detection of CS was 52% with a specificity of 82%. For the entire cohort, SAECG had a positive predictive value (PPV) of 0.56 and a negative predictive value (NPV) of 0.79. Within a subgroup of 67 patients with an unfiltered QRS duration of <100 ms, the specificity for diagnosing cardiac sarcoidosis improves to 100% with a reduced sensitivity of 36.8. Of the SAECG parameters, LAS40 was significantly associated with the diagnosis of cardiac sarcoidosis for the entire cohort (P < 0.01) and among the subgroup of patients with an unfiltered QRS duration of <100 ms (P < 0.01).

Conclusions: SAECG is a useful screening tool in the evaluation of sarcoidosis for detection of cardiac involvement.

Ann Noninvasive Electrocardiol 2011;16(1):70–76
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: electrophysiology - ventricular tachycardia < clinical; noninvasive techniques; signal-averaged ECG < clinical

Document Type: Research Article

Affiliations: Section of Cardiac Electrophysiology, University of Colorado, and Division of Cardiology, National Jewish Health, Denver, CO

Publication date: January 1, 2011

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more