Skip to main content
padlock icon - secure page this page is secure

Correlation of Modification of Heart Rate Recovery with Adaptation to Myocardial Ischemia in a Model of Sequential Exercise Testings

Buy Article:

$47.00 + tax (Refund Policy)

Background: Heart rate recovery (HRR) has been identified as a reliable predictor of cardiac mortality, correlated with autonomic tone. In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia.

Methods: We studied 128 patients (mean age 62 ± 9 years, 83% males) with angiographically documented coronary artery disease (CAD) and a first positive exercise testing, who agreed to undergo a second exercise testing after 24 hours.

Results: HRR was increased from 25 ± 10 beats/min at the first exercise testing to 30 ± 13 beats/min at the second exercise testing (P < 0.001). Thereafter, participants were divided into two groups: Group I comprised 88 patients who presented augmentation of the HRR in the first compared to the second exercise testing, while group II comprised 40 patients who presented unchanged or reduced HRR. The rate-pressure product (RPP) at 1 mm ST-segment depression (ischemic threshold) at the second compared to the first exercise testing were significantly improved in group I patients (2345 ± 3429 mmHg/min), while it was worsened in group II patients (−630 ± 2510 mmHg/min) (P < 0.001).

Conclusions: In a model of sequential exercise testings, myocardial adaptation to exercise-induced ischemia was associated with favorable modification of HRR.

Ann Noninvasive Electrocardiol 2008;13(4):364–370
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: coronary artery disease; exercise testing; heart rate recovery; myocardial ischemic preconditioning

Document Type: Research Article

Affiliations: First Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece

Publication date: October 1, 2008

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more