Variable Interatrial Conduction Illustrated in a Hypertrophic Cardiomyopathy Population
Methods and Results: A total of 65 patients (45 men, mean age 49 ± 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 ± 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed.
The P-wave duration was longer in the HCM patients compared to the controls (149 ± 22 vs 130 ± 16 ms, P < 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z.
Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes.
Document Type: Research Article
Affiliations: 1: Department of Cardiology, Lund University Hospital, Lund, Sweden 2: The Cardiothoracic Centre, Liverpool, United Kingdom 3: The Heart Hospital, University College London, United Kingdom
Publication date: July 1, 2007