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Oestrogen receptors in the developing rat prostate

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This study aimed to illustrate the histological picture of the developing rat prostate and to localise the oestrogen receptors (ERs) distribution. Fifty male albino rats were divided into five equal subgroups: subgroup 1, rats aged 2 days (before morphogenesis of prostate from urogenital sinus); subgroup 2, rats aged 1 week (after early morphogenesis); subgroup 3, rats aged 2 weeks (early pubertal stage); subgroup 4, rats aged 4 weeks (late pubertal stage) and subgroup 5 rats aged 6 weeks (maturation stage). After the rats had been killed, the prostates were dissected and specimens were obtained from the anterior lobe. Paraffin sections of these specimens were subjected to haematoxylin and eosin stain, immunohistochemistry and quantitative immunohistohemistry for ERs distribution and the area of strong positive cytoplasmic immunoreactivity. The results demonstrated that ERs protein decreased gradually with increased age and that it decreased markedly with the onset of puberty. It is concluded that the prostate despite being an androgen dependent gland, depends greatly on oestrogen in its development in the prepubertal period.
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Keywords: Genital tract; males; oestrogen; prostate; receptors

Document Type: Research Article

Affiliations: 1:  Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt 2:  Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt

Publication date: April 1, 2011

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