Comparison of remifentanil with alfentanil or suxamethonium following propofol anaesthesia for tracheal intubation
Sixty ASA physical status I and II, premedicated patients were administered propofol 2 mg.kg-1 and remifentanil 2 μg.kg-1 (group R), alfentanil 50 μg.kg-1 (group A) or suxamethonium 1 mg.kg-1 (group S) as a rapid bolus. One minute after study drug administration, tracheal intubation was performed. Intubation conditions were then scored. Excellent or good conditions were observed in only 35% in group R compared with groups S and A (100% and 85%, respectively; p < 0.001). The haemodynamic response to tracheal intubation was blunted in groups R and A compared with group S (p < 0.001). The mean heart rate in groups R and A was significantly lower than group S (p < 0.001). We conclude that remifentanil 2 μg.kg-1 given as a rapid bolus will not produce intubating conditions as good as those obtained with alfentanil 50 μg.kg-1 or suxamethonium 1 mg.kg-1 if administered after propofol 2 mg.kg-1.
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Document Type: Research Article
Affiliations: Department of Anesthesiology, Box 3094, Duke University Medical Centre, Durham, NC 27710, USA
Publication date: November 1, 1999