Skip to main content
padlock icon - secure page this page is secure

Free Content Worldwide FST Estimates Relative to Five Continental‐Scale Populations

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

We estimate the population genetics parameter FST (also referred to as the fixation index) from short tandem repeat (STR) allele frequencies, comparing many worldwide human subpopulations at approximately the national level with continental‐scale populations. FST is commonly used to measure population differentiation, and is important in forensic DNA analysis to account for remote shared ancestry between a suspect and an alternative source of the DNA. We estimate FST comparing subpopulations with a hypothetical ancestral population, which is the approach most widely used in population genetics, and also compare a subpopulation with a sampled reference population, which is more appropriate for forensic applications. Both estimation methods are likelihood‐based, in which FST is related to the variance of the multinomial‐Dirichlet distribution for allele counts. Overall, we find low FST values, with posterior 97.5 percentiles <3% when comparing a subpopulation with the most appropriate population, and even for inter‐population comparisons we find FST <5%. These are much smaller than single nucleotide polymorphism‐based inter‐continental FST estimates, and are also about half the magnitude of STR‐based estimates from population genetics surveys that focus on distinct ethnic groups rather than a general population. Our findings support the use of FST up to 3% in forensic calculations, which corresponds to some current practice.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: FST; Microsatellite; fixation index; forensic; short tandem repeat

Document Type: Research Article

Publication date: November 1, 2014

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more