Skip to main content
padlock icon - secure page this page is secure

Free Content A Note on the Asymptotic Properties of Affected-sib-pair Linkage Tests

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library


This article concerns the asymptotic properties of linkage tests for affected-sib-pair data under the null hypothesis of no linkage. We consider a popular single-locus analysis model where the unknown parameters are the disease allele frequency, the three penetrances for the three genotypes at the disease locus, and the recombination fraction between the marker locus and the disease locus. These parameters are completely confounded under the null hypothesis of no linkage. We show that 1) If the total variance of the trait (i.e., the additive variance plus the dominance variance) is “separated” from 0, then the likelihood ratio statistic has an asymptotic 0.520+ 0.521 distribution; 2) If the prevalence of the trait is “separated” from 0 and the recombination fraction is fixed at 0, then the likelihood ratio statistic has an asymptotic distribution which is a mixture of 20, 21 and 22 . The implications of these results are discussed.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ASP; likelihood ratio test; mean test; score test

Document Type: Short Communication

Publication date: July 1, 2004

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more