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Free Content Molecular characterization of isochromosomes of Xq

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We have undertaken a study of 35 patients with i(Xq) to determine whether those that are maternally derived originate by similar mechanisms to those that are paternally derived. Isochromosome formation is not associated with increased parental age and >90% of i(Xq) contain proximal Xp sequences suggesting that centromere misdivision is not a common mechanism of formation. Our results indicate that the majority of i(Xq) originate from a single X chromosome and the usual mechanisms of formation do not appear to differ according to the parent of origin.
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Document Type: Research Article

Affiliations: 1: Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts SP2 8BJ, UK 2: Department of Genetics, Case Western Reserve University, 2109 Adelbert Road, Cleveland OH 44106, USA

Publication date: November 1, 1997

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