Metformin reduces vascular production of vasoconstrictor prostanoids in fructose overloaded rats
1 Metformin is a hypoglycaemic drug currently used to increase insulin sensitivity in the treatment of type 2 diabetes and metabolic syndrome. Its main mechanism of action is through activation of
2 The fructose‐overloaded rat is an experimental model with features that resemble human metabolic syndrome. We have previously reported alterations in vascular prostanoids (
3 The aim of this study was to analyse the effects of metformin treatment on blood pressure, metabolic parameters and
4 Rats with fructose overload had significantly elevated systolic blood pressure, glycaemia, triglyceridaemia, cholesterolaemia and insulinaemia compared with controls. Except for insulinaemia, metformin limited all these increases in fructose‐overloaded animals.
5 Fructose overload reduced prostacyclin levels in aorta and
6 In conclusion, one of the mechanisms by which metformin reduced blood pressure in this model is by decreasing vasoconstrictor prostaglandin production.
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Document Type: Research Article
Publication date: April 1, 2012