Skip to main content
padlock icon - secure page this page is secure

Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways

Buy Article:

$52.00 + tax (Refund Policy)


1 The effect of montelukast or MEN91507, selective leucotriene CysLT1 receptor antagonists, on antigen-induced airway inflammation and bronchoconstriction were compared in anaesthetized guinea-pigs.

2 In sensitized animals, ovalbumin (0.3 mg kg−1, i.v.)-induced microvascular leakage in trachea, intrapulmonary airways, total lung (parenchyma and intrapulmonary airways) and urinary bladder was reduced by MEN91507 (0.01–1 mol kg−1, i.v.), whereas montelukast (0.01–1 mol kg−1, i.v.) antagonized the effect of the antigen only in the lung and urinary bladder.

3 Ovalbumin (1 mg kg−1, i.v.)-induced bronchoconstriction was dose dependently antagonized by MEN91507 (10–30 mol kg−1, i.v.), whereas the effect of montelukast (0.1–30 mol kg−1, i.v.) was marginal (15–30% inhibition). Neither MEN91507 nor montelukast (30 mol kg−1, i.v.) affected the bronchoconstrictor response induced by acetylcholine (0.3 mol kg−1, i.v.) in sensitized animals.

4 It is concluded that montelukast and MEN91507 display a differential activity against the effect of endogenous leucotrienes, despite the fact that both compounds show a similar antagonist profile against exogenous leucotrienes acting through CysLT1 receptors.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: MEN 91507; allergy; asthma; bronchoconstriction; montelukast; urinary bladder

Document Type: Research Article

Affiliations: 1: Department of Pharmacology, School of Pharmacy, Central University of Venezuela, Caracas, Venezuela 2: Pharmacology Department, Menarini Ricerche, via Sette Santi 1, 50131 Florence, Italy 3: Pharmacokinetics and Metabolism Department, Menarini Ricerche, via Tito Speri 10, 00040 Pomezia, Rome Italy

Publication date: January 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more