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Vascular α1-adrenoceptors in isolated perfused rat kidney: influence of ageing

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Summary

1 The present study identifies α1-adrenoceptor subtype(s) involved in constrictor responses of the kidney and how ageing influences it.

2 The study was conducted on kidneys from F344BNF1 rats, which unlike F344 or Wistar rats used by many previous investigators do not exhibit glomerulonephritis at advanced age.

3 Noradrenaline (NA) and phenylephrine (PHE) (non-selective α1) and A61063 (selective α1A) adrenoceptor agonists elicited constriction of perfused kidneys of young and old rats. The pD2 values (index of renovascular reactivity) were significantly higher for A61603 than for either PHE or NA, and significantly decrease across age groups.

4 BMY 7378 or RS 100329, α1D- or α1A-adrenoceptor antagonists, respectively antagonized the constrictor responses and suppressed the maximal responses to all agonists in young adult rat kidneys. However, antagonism of PHE or A61063 by BMY 7378 in old rat kidneys was surmountable.

5 This study suggests that: (i) α1A and α1D-adrenoceptor subtypes mediate vasoconstriction of perfused rat kidney; (ii) α1A-adrenoceptor subtype appears to predominate in renal vasculature based on agonist relative potencies. (iii) Ageing significantly decreases α1-adrenoceptor-mediated vasoconstriction of rat kidney.
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Keywords: ageing; perfused kidney; vasoconstriction; α1-adrenoceptor subtypes

Document Type: Research Article

Publication date: 01 January 2007

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