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Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis

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ARV1 is involved in regulating lipid homeostasis but also in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. Here, we examined whether human ARV1 can complement the role of yeast ARV1 in GPI biosynthesis. Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Δ mutant. The results suggest that Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. Copyright © 2015 John Wiley & Sons, Ltd.
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Keywords: GPI anchor; arv1Δ mutant; complementation; human ARV1; yeast

Document Type: Research Article

Publication date: February 1, 2016

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