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Temporary storage of fresh frozen plasma above −30°C has no negative impact on the quality of clotting factors and inhibitors

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SUMMARY

Fresh frozen plasma (FFP) should be stored at temperatures > −30°C according to national and international guidelines to maintain the stability of clotting factors and inhibitors. In the present report, FFP was accidentally stored at < −30°C due to icing of the freezer. To ensure the quality of the FFPs a battery of tests of clotting factors and inhibitors was performed. Our data demonstrate that temporary storage of FFP at temperature < −30°C does not negatively affect the quality of FFPs. The European requirement of 70% activity of factor VIII was met by all units.
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Keywords: plasma quality; plasma storage temperature

Document Type: Research Article

Affiliations: 1: Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany 2: University Clinic for Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria

Publication date: 01 March 2010

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