Hyphenation of capillary high‐performance ion‐exchange chromatography with mass spectrometry using sheath‐flow electrospray ionization
Mass spectrometry (MS) is an attractive method for extending capillary‐size ion chromatography (cHPIC) to create a valuable technique for speciation analysis. For hyphenation, the aqueous effluent of cHPIC has to be transformed into a volatile mixture for MS while preserving analytical concentrations as well as peak shapes during transfer from cHPIC to MS. Finally, the approach should technically be flexible and easy‐to‐use. A combination of cHPIC and sheath‐flow electrospray ionization (ESI)‐MS offers to solve all these challenges.
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Document Type: Research Article
Publication date: December 15, 2014